AffiCELL® Recombinant Human R-spondin-1 (RSPO1) (Active)
CAT# AFG-CZB-010
Size: 50 μg
Available Sizes: 1 mg, 500 μg, 50 μg, 10 μg
Overview
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1.
Product types
Active Protein & In Stock Protein.
Research Areas
Developmental Biology.
Gene Names
RSPO1.
Alternative Name
RSPO1; R-spondin1; RP11-566C13.1; CRISTIN3; FLJ40906; RSPO Rspo1; R-spondin; Rspondin; RP23-325M14.2; Roof plate-specific spondin-1.
Organism
Homo sapiens (Human) .
Source
Mammalian cell.
Expression Region
21-263aa.
Protein Length
Full Length of Mature Protein.
Tag Info
C-terminal 6xHis-tagged.
Molecular Weight
27.8 kDa.
Purity
Greater than 95% as determined by SDS-PAGE..
Storage Conditions
The shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.