Siglec Cell Line 

Siglec Cell Lines are specialized cell lines genetically engineered to express members of the Sialic acid-binding Immunoglobulin-like Lectins (Siglec) family. Siglecs are a group of cell surface receptors predominantly found on immune cells, playing critical roles in immune modulation, cell signaling, and pathogen recognition. 

Content

• Purpose:
  • Provide a reliable model to investigate Siglec-mediated immune responses and signaling pathways.
• Characteristics:
  • Expression Systems: Engineered to overexpress human or murine Siglec proteins in cell lines such as HEK293, CHO, or Jurkat.
  • Surface Expression: Verified using flow cytometry or immunofluorescence assays.
  • Functional Integrity: Retains native signaling capabilities and ligand-binding specificity.
• Types of Siglec Cell Lines:
  • Individual Siglec cell lines (e.g., Siglec-2, Siglec-7, Siglec-10).

Applications

• Immunology Research:
  • Study Siglec-mediated regulation of immune cell activation and inhibition.
• Drug Discovery:
  • Screen potential inhibitors or agonists targeting Siglec pathways for autoimmune diseases and cancer immunotherapy.
• Oncology:
  • Assess the role of Siglecs in tumor immune evasion and metastasis.
• Infectious Diseases:
  • Explore how pathogens exploit Siglec interactions to evade immune responses.

Siglec Cell Lines are invaluable tools for advancing our understanding of immune regulation and therapeutic targeting, offering insights into diseases such as cancer, autoimmune disorders, and infections.